YouTube Live was a 2008 event streamed live on the Internet from San Francisco and Tokyo. It was launched November 22–23, 2008. It was hosted by a variety of YouTube celebrities, including The Black Eyed Peas rapper will.i.am, Tom Dickson of Will It Blend, Michael Buckley, The Happy Tree Friends, Fred, Smosh, Esmée Denters, Bo Burnham and singer Katy Perry among others. On April 8, 2011, the channel was closed, effectively removing all videos. It was replaced by the YouTube live section page.

Jordinian Queen Rania was also honoured at the event with the first YouTube Visionary Award for her efforts to combat stereotypes and misconceptions associated with Arabs and Muslims. With over 3 million views, Queen Rania created her own channel on YouTube in March 2008 to start an international conversation, which she called "unscripted, unedited and unfiltered".

As a sponsor for the event, Flip Video gave away a free Flip Video Mino to many of the audience members to record any of the event. A station to upload videos to YouTube from the Mino was also provided, and promoted, in sponsorship of Flip.

The event was meant to be an annual show, as referenced by Katy Perry at the beginning; however, it remains the only event to date.