Harley Davidson and the Marlboro Man is a 1991 American neo-Western biker film starring Mickey Rourke and Don Johnson, with a supporting cast including Chelsea Field, Tom Sizemore, Daniel Baldwin, Giancarlo Esposito, and Vanessa Williams who also contributes to the film's soundtrack. It was directed by Simon Wincer from a screenplay by Don Michael Paul.

The film was a critical and financial failure, grossing $7 million at the domestic box office, against an estimated budget of $23 million.