Bloodhounds of Broadway is a 1989 American ensemble period comedy film based on four Damon Runyon stories: "The Bloodhounds of Broadway", "A Very Honorable Guy", "The Brain Goes Home" and "Social Error". Directed by Howard Brookner, it stars Matt Dillon, Jennifer Grey, Anita Morris, Julie Hagerty, Rutger Hauer, Madonna, Esai Morales and Randy Quaid. Madonna and Jennifer Grey perform a duet, "I Surrender Dear", during the film. Madonna earned a Golden Raspberry Award nomination for Worst Supporting Actress for her performance in the film, where she lost to Brooke Shields for Speed Zone.

Bloodhounds of Broadway was Brookner's only feature-length film; he died shortly before the film opened. The film was recut by the studio and Walter Winchell-esque narration was added. The film received negative reviews. Six months following its theatrical release, the film was televised as a presentation of PBS's American Playhouse on May 23, 1990.