The 2010 Lockdown was a professional wrestling pay-per-view (PPV) event produced by the Total Nonstop Action Wrestling (TNA) promotion, which took place on April 18, 2010 at the Family Arena in Saint Charles, Missouri. It was the sixth event under the Lockdown chronology and the fourth event of the 2010 TNA PPV schedule. As per the theme of Lockdown events, every match took place inside a steel cage. It was the first Lockdown event with a four-sided steel cage.

In October 2017, with the launch of the Global Wrestling Network, the event became available to stream on demand.