Riding the Bus with My Sister is a 2005 television film that aired on CBS as part of the Hallmark Hall of Fame anthology series, based on the 2002 memoir of the same name by Rachel Simon. The film, like the book, is about the time Simon spent with her sister Beth, who has a developmental disability, and whose lifestyle revolves around riding buses in her home city of Reading, Pennsylvania. Andie MacDowell plays Rachel Simon, while Rosie O'Donnell plays Beth. It was directed by Anjelica Huston, with a screenplay by Joyce Eliason.

Riding the Bus with My Sister was filmed in Hamilton, Ontario, Canada.