Kristian (Mugge), Casper (Søgaard), and Jakob (Nasser) are friends and neighbours and share a friendship based on humour and irony, and as all other young men, they all take a great interest in film, sports, girls, sex and partying. They also share, however, some seriously challenging living terms; all three of them suffer from Progressive Muscular Dystrophy, and thus - with a pinch of characteristic black humour - refer to themselves as the "Skin and Bones" guys.

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