Girlfriends is a 1978 American comedy drama film produced and directed by Claudia Weill and written by Vicki Polon. The film stars Melanie Mayron as Susan Weinblatt, a Jewish photographer who experiences loneliness once her roommate Anne (Anita Skinner) moves out of their apartment in New York City. It was the first American independent film to be funded with grants, but private investors helped complete the film.

Although the film began shooting in November 1975, it took almost three years to complete because the initial budget of $80,000 ran out. After the film was picked up for distribution by Warner Bros., it was released on August 11, 1978.

In 2019, the film was selected for preservation in the United States National Film Registry by the Library of Congress as being "culturally, historically, or aesthetically significant".