Le Chambon-sur-Lignon (French pronunciation: [lə ʃɑ̃bɔ̃ syʁ liɲɔ̃], literally "Le Chambon on Lignon"; Auvergnat: Lo Chambon) is a commune in the Haute-Loire department in south-central France.

Residents have been primarily Huguenot or Protestant since the 17th century. During World War II these Huguenot residents made the commune a haven for Jews fleeing from the Nazis. They hid them both within the town and in the countryside, and helped them flee to neutral Switzerland. In 1990 the town was one of two collectively honoured as the Righteous Among the Nations by Yad Vashem in Israel for saving Jews in Nazi-occupied Europe. The other awardee was the Dutch village of Nieuwlande.