Dylan Dog: Dead of Night is a 2011 American action horror-comedy film based on Tiziano Sclavi's Italian comic book Dylan Dog, starring Brandon Routh as the antagonisted eponymous and self-aware detective who investigates cases involving the vampires, zombies, and werewolves of New Orleans.

Directed by Kevin Munroe and written by Thomas Dean Donnelly and Joshua Oppenheimer, the film co-stars Sam Huntington, Anita Briem, Peter Stormare, and Taye Diggs. The film was released by Omni/Freestyle Releasing in the United States on April 29, 2011. The film received negative reviews from critics, and was a box-office bomb after grossing just $5.8 million on a $20 million budget.