Twice in a Lifetime is a 1985 American drama film directed by Bud Yorkin and starring Gene Hackman as a married steelworker in a mid-life crisis who becomes attracted to another woman, played by Ann-Margret. Ellen Burstyn, Amy Madigan, Ally Sheedy, and Brian Dennehy co-star. The film is a remake of the 1973 BBC drama, Kisses at Fifty, by the same writer.

Paul McCartney composed and performed the theme song to the film, heard over the end credits. It remained commercially unavailable as a recording until 1993 when it was included as a bonus track on a reissue of McCartney's album Pipes of Peace.