Annihilation is a 2018 Lovecraftian science fiction horror thriller film written and directed by Alex Garland, loosely based on the 2014 novel of the same name by Jeff VanderMeer. It stars Natalie Portman, Jennifer Jason Leigh, Gina Rodriguez, Tessa Thompson, Tuva Novotny, and Oscar Isaac. The story follows a group of scientists who enter the Shimmer, a mysterious quarantined zone of mutating plants and animals caused by an alien presence.

Released theatrically in the United States by Paramount Pictures on February 23, 2018, and in China on April 13, Annihilation was released digitally by Netflix in a number of other countries on March 12, 2018. It received positive reviews from critics and grossed $43 million worldwide. According to Empire magazine, the film addresses 'depression, grief, and the human propensity for self-destruction'.