Captain Underpants: The First Epic Movie is a 2017 American animated superhero comedy film based on Dav Pilkey's children's novel series, titled Captain Underpants, produced by DreamWorks Animation and distributed by 20th Century Fox. The film is directed by David Soren from a screenplay by Nicholas Stoller, and stars the voices of Kevin Hart, Ed Helms, Nick Kroll, Thomas Middleditch, Jordan Peele, and Kristen Schaal, the film was released during the 20th anniversary of the Captain Underpants series. In the film, two fourth-grade pranksters, named George and Harold, hypnotize their humorless principal, named Mr. Krupp, into thinking he is a superhero, named Captain Underpants. The film loosely adapts the first, the second, the fourth, and the eleventh Captain Underpants books.

Captain Underpants: The First Epic Movie first premiered at the Regency Village Theatre, in Los Angeles, California, in the United States, on May 21, 2017, and was first released theatrically in theaters, in the United States, on June 2, 2017, in both 2-D and 3-D formats. The film received positive reviews, with critics praising the animation, humor, faithfulness, references to its source material, and voice acting. It grossed $125 million worldwide against a budget for $38 million, the lowest budget for a film from DreamWorks Animation, until 2021, with Spirit Untamed, which had a budget for $30 million. It was the final DreamWorks Animation film to be distributed by 20th Century Fox, following their acquisition by NBCUniversal in 2016. Universal Pictures began to distribute films from DreamWorks, starting with How to Train Your Dragon: The Hidden World (2019).

A spin-off television series, titled The Epic Tales of Captain Underpants, premiered on Netflix on July 13, 2018, while a spin-off film, titled Dog Man, was released by Universal Pictures on January 31, 2025.