Captain Underpants: The First Epic Movie is a 2017 American animated superhero comedy film based on Dav Pilkey's children's novel series, titled Captain Underpants, produced by DreamWorks Animation and distributed by 20th Century Fox. The film is directed by David Soren from a screenplay by Nicholas Stoller, and stars the voices of Kevin Hart, Ed Helms, Thomas Middleditch, and Nick Kroll. In the film, two fourth-grade pranksters, named George and Harold, hypnotize their humorless principal, named Mr. Krupp, into thinking he is a superhero named Captain Underpants. The film loosely adapts the first, the second, the fourth, and the eleventh Captain Underpants books.

Captain Underpants: The First Epic Movie first premiered at the Regency Village Theater, in Los Angeles, California, in the United States, on May 21, 2017, and was first released theatrically in movie theaters, in the United States, on June 2, 2017, both in the 2-D and in the 3-D formats. The film received positive reviews, with critics praising the animation, humor, faithfulness, references to its source material, and voice acting. It grossed $125 million worldwide against a budget for $38 million, the lowest budget for a film from DreamWorks Animation, until 2021, with Spirit Untamed, which had a budget for $30 million. It was the final DreamWorks Animation film to be distributed by 20th Century Fox, following the acquisition of DreamWorks Animation by both Comcast and NBCUniversal in 2016 and the acquisition of 21st Century Fox by Disney in 2017.

A spin-off television series, titled The Epic Tales of Captain Underpants, premiered on Netflix on July 13, 2018, while a spin-off film, titled Dog Man, was released by Universal on January 31, 2025.