Pain Hustlers is a 2023 American crime comedy film co-produced and directed by David Yates from a screenplay by Wells Tower, based on the 2022 book of the same name by Evan Hughes. The film is loosely based on the activities of the real world company Insys Therapeutics and their role in the US opioid crisis. The film stars Emily Blunt, Chris Evans, Andy García, Catherine O'Hara, Jay Duplass, Brian d'Arcy James, and Chloe Coleman. Its plot centers on a high school dropout who lands a job with a failing pharmaceutical company in Central Florida, where she soon finds herself at the center of a criminal conspiracy.

Pain Hustlers had its premiere at the Toronto International Film Festival on September 11, 2023, and was released in select theaters in the United States on October 20, before its streaming debut by Netflix on October 27. The film received generally negative reviews from critics.