Damien: Omen II is a 1978 supernatural horror film directed by Don Taylor and the second installment of The Omen series. It stars William Holden and Lee Grant, with Jonathan Scott-Taylor, Robert Foxworth, Lew Ayres, Sylvia Sidney, Lance Henriksen, Ian Hendry, and Leo McKern. Set seven years after the first film, it follows a now-pubescent Damien Thorn (Scott-Taylor) as he begins to realize his destiny as the Antichrist.

Franchise producer Harvey Bernhard wrote the screen story, with a screenplay by Stanley Mann and Mike Hodges. Hodges was the original director, but was replaced by Don Taylor early in production. Unlike the first film, which was shot in England and Italy, filming of the sequel took place primarily in Chicago, Wisconsin, and Israel.

It was released by 20th Century Fox on June 9, 1978, and received mixed reviews from critics. A sequel, Omen III: The Final Conflict, was released in 1981.