The 2021 Bound for Glory was a professional wrestling pay-per-view event produced by Impact Wrestling. It took place on October 23, 2021, at Sam's Town Live in Sunrise Manor, Nevada. This was Impact Wrestling's first event to take place outside of Nashville, Tennessee, since March 2020. It was the 17th event under the Bound for Glory chronology and featured wrestlers from Impact's partner promotions All Elite Wrestling (AEW), Mexico's Lucha Libre AAA Worldwide (AAA), and Japan's New Japan Pro-Wrestling (NJPW).

Nine matches were contested at the event, including one on the pre-show. In what had been the advertised main event, Josh Alexander defeated Christian Cage to win the Impact World Championship. However, Moose invoked his Call Your Shot Gauntlet championship match privilege (which he won earlier in the night) to immediately challenge and defeat Alexander, winning the World Championship in front of his family to close the show.

In other prominent matches, Mickie James defeated Deonna Purrazzo to win the Impact Knockouts Championship, Trey Miguel defeated El Phantasmo and Steve Maclin in a tournament final three-way match to win the vacant Impact X Division Championship, and in the opening bout, the debuting The IInspiration (Cassie Lee and Jessica McKay) defeated Decay (Havok and Rosemary) to win the Impact Knockouts Tag Team Championship.