Muppets from Space, alternatively known as The Muppets from Space, is a 1999 American science fiction comedy film directed by Tim Hill, written by Jerry Juhl, Joseph Mazzarino, and Ken Kaufman, produced by Brian Henson and Martin G. Baker, and the sixth theatrical film featuring the Muppets. The film stars Muppet performers Dave Goelz, Steve Whitmire, Jerry Nelson, Bill Barretta, and Frank Oz, as well as Jeffrey Tambor, F. Murray Abraham, David Arquette, Josh Charles, Hollywood Hogan, Ray Liotta, Rob Schneider and Andie MacDowell. In the film, Gonzo attempts to discover his origins. After he and Rizzo the Rat are captured by government officials during his search, Kermit the Frog and the rest of the Muppets set out to rescue them.

The film was released on July 14, 1999. It grossed $22.3 million against a budget of $24 million, making it a box office failure, and received mixed reviews from critics; many considered it the weakest theatrical Muppet movie. It is the last Muppet film to have the involvement of Oz and Juhl and the last theatrically-released Muppet film to be produced by The Jim Henson Company before the franchise was acquired by The Walt Disney Company in 2004.