The PFL 10 mixed martial arts event for the 2021 season of the Professional Fighters League was held on October 27, 2021. This was the finale of the playoffs for all divisions, with the winners getting $1 million cash prize. Kayla Harrison, a two-time Olympic gold medalist in judo and is seeking her second PFL championship, headlined the PFL event opposite Taylor Guardado, who emerged as an unexpected finalist in 2021. The event also featured five other finals matchups, with the winner of each weight class taking home PFL's trademark $1 million prize.

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