The Secret of the Blue Room is a 1933 American pre-Code mystery film directed by Kurt Neumann and starring Lionel Atwill, Gloria Stuart, Paul Lukas, and Edward Arnold. A remake of the German film Geheimnis des blauen Zimmers (1932), it concerns a group of wealthy people who stay at a European mansion that features a blue room that is said to be cursed, as everyone who has stayed there has died shortly after. Three people suggest a wager that each can survive a night in the blue room.

Filmed over a six-day period in June 1933, The Secret of the Blue Room was Universal Pictures' least-expensive production that year. It was released theatrically in July 1933, and was met by mixed reviews from critics, receiving praise for its performances, but criticism for its formulaic plot devices. Universal later remade the film as The Missing Guest (1938) and Murder in the Blue Room (1944).