Tony Rome is a 1967 American neo-noir mystery crime thriller film directed by Gordon Douglas and starring Frank Sinatra in the title role, alongside Jill St. John, Sue Lyon and Gena Rowlands. It was adapted from Marvin H. Albert's novel Miami Mayhem.

The story follows the adventures of Miami private investigator Tony Rome (Sinatra) in his quest to locate a missing diamond pin that belongs to a wealthy heiress.

A sequel, Lady in Cement, was made in 1968, again featuring Sinatra as Tony Rome, and co-starring Raquel Welch and Dan Blocker. Appearing in both films was Richard Conte as Miami police lieutenant Dave Santini.

Both films are examples of a late-1960s neo-noir trend that revived and updated the hard-boiled detective and police dramas of the 1940s. Other films in this genre include The Detective (1968), which also starred Sinatra, as well as Point Blank (1967), Bullitt (1968), Madigan (1968) and Marlowe (1969).