The Defiant Ones is a 1958 American adventure drama film which tells the story of two escaped prisoners, one white and one black, who are shackled together and who must co-operate in order to survive. It stars Tony Curtis and Sidney Poitier.

The film was adapted by Harold Jacob Smith from the story by Nedrick Young, originally credited as Nathan E. Douglas. It was produced and directed by Stanley Kramer.

The film was highly regarded at the time of its release; it won Academy Awards for Cinematography (Black-and-White) and Original Screenplay and was nominated for seven others, including Best Picture and Best Actor for both Poitier and Curtis. Poitier won the Silver Bear for Best Actor at the Berlin International Film Festival.