The Substance is a 2024 body horror film written, directed, co-edited, and co-produced by Coralie Fargeat. It follows a fading celebrity (Demi Moore) who uses a black market drug that creates a much younger version of herself (Margaret Qualley) with unexpected side effects. Dennis Quaid also stars.

An international co-production between France, the United Kingdom, and the United States, the film had its world premiere on 19 May 2024 at the 77th Cannes Film Festival main competition, where Fargeat won Best Screenplay. It was released theatrically in the United Kingdom and the United States by Mubi on 20 September 2024, and in France by Metropolitan Filmexport on 6 November 2024. The film was a critical and commercial success, earning over $55 million on a $17.5 million production budget.