The 2022 NXT In Your House was the 30th and final In Your House professional wrestling event produced by WWE, and the third annual and final held for the promotion's NXT brand division. It took place on Saturday, June 4, 2022, at the WWE Performance Center in Orlando, Florida and aired on WWE's livestreaming platforms.

In June 2020, WWE revived In Your House as a subseries of the NXT TakeOver series. In September 2021, however, the TakeOver series was discontinued after NXT reverted to being WWE's developmental brand. With the scheduling of this 2022 event, In Your House became its own event for NXT. Unlike the previous year's event, which also aired on pay-per-view (PPV), the 2022 event was only available via livestreaming, as beginning with Stand & Deliver in April, NXT's major events no longer air on PPV. This would also be the final In Your House as an event was not scheduled for 2023.

Eight matches were contested at the event, including two dark matches that were later streamed on Level Up. All five championships exclusive to the NXT brand were contested for; two were lost while the other three were retained. In the main event, Bron Breakker defeated Joe Gacy to retain the NXT Championship. In other prominent matches, The Creed Brothers (Brutus Creed and Julius Creed) defeated Pretty Deadly (Elton Prince and Kit Wilson) to win the NXT Tag Team Championship, Carmelo Hayes defeated Cameron Grimes to win the NXT North American Championship, and in the opening bout, The D'Angelo Family (Tony D'Angelo, Channing "Stacks" Lorenzo, and Troy "Two Dimes" Donovan) defeated Legado Del Fantasma (Santos Escobar, Cruz Del Toro, and Joaquin Wilde).