Who Framed Roger Rabbit is a 1988 American fantasy comedy film directed by Robert Zemeckis from a screenplay written by Jeffrey Price and Peter S. Seaman. It is loosely based on the 1981 novel Who Censored Roger Rabbit? by Gary K. Wolf. The film stars Bob Hoskins, Christopher Lloyd, Stubby Kaye, and Joanna Cassidy, along with the voices of Charles Fleischer and an uncredited Kathleen Turner. Combining live-action and animation, the film is set in an alternate history Hollywood in 1947, where humans and cartoon characters (referred to as "toons") co-exist. Its plot follows Eddie Valiant, a private investigator with a grudge against toons, who must help exonerate Roger Rabbit, a toon framed for murder.

Walt Disney Pictures purchased the film rights for the story in 1981. Price and Seaman wrote two drafts of the script before Disney brought in executive producer Steven Spielberg and his production company, Amblin Entertainment. Zemeckis was brought on to direct, and Canadian animator Richard Williams was hired to supervise the animation sequences. Production was moved from Los Angeles to Elstree Studios in England to accommodate Williams and his group of animators. While filming, the production budget rapidly expanded, and the shooting schedule ran longer than expected.

Who Framed Roger Rabbit was released through Disney's Touchstone Pictures banner in the United States on June 22, 1988. The film received critical acclaim for its visuals, humor, writing, performances, and groundbreaking combination of live-action and animation. It grossed over $351 million worldwide, becoming the second-highest-grossing film of 1988, behind Rain Man. It brought a renewed interest in the golden age of American animation, spearheading modern American animation and the Disney Renaissance. It won three Academy Awards for Best Film Editing, Best Sound Effects Editing and Best Visual Effects and received a Special Achievement Academy Award for Williams' animation direction.

In 2016, the film was selected for preservation in the United States National Film Registry by the Library of Congress as "culturally, historically, or aesthetically significant".