The Goddamn George Liquor Program is a 1997 Adobe Flash animated web series created by John Kricfalusi and starring the animated character George Liquor. It was originally developed as a web-based cartoon by Microsoft's then-new MSN, in partnership with Spümcø studio. After failing to receive approval for publishing from Microsoft, all properties were released to Spümcø, and the web-based cartoon was spun out directly by the Spümcø studio. Michael Pataki reprised his role as Liquor from The Ren & Stimpy Show. Spümcø produced eight one-minute shorts. The budget for each episode was $25,000.

Premiering on October 15, 1997, The Goddamn George Liquor Program was the first animated cartoon series to be produced exclusively for the internet. George appeared on the series with his nephew, Jimmy The Idiot Boy; Jimmy's cousins, Slab and Ernie; Jimmy's love interest, Sody Pop; and George and Jimmy's pet dog, Dirty Dog. Without the control of a network, the series could be made as Kricfalusi wanted. The Goddamn George Liquor Program won the 1999 Annie Award for "Outstanding Achievement in an Animated Interactive Production". Later the show was being developed as a series of cartoon commercials for Pontiac Vibe. The new series remained unreleased after General Motors discontinued the Pontiac Vibe auto line in 2009.