Jon Stewart: The Kennedy Center Mark Twain Prize for American Humor was a variety special that aired June 21, 2022 on PBS. The show honored comedian Jon Stewart who was being awarded with the Mark Twain Prize for American Humor which was presented at the John F. Kennedy Center for the Performing Arts in Washington D.C. Those who helped celebrate his accomplishments included Dave Chappelle, Steve Carell, John Oliver, Stephen Colbert, Ed Helms, Olivia Munn, Samantha Bee, Bassem Youssef, Jon Meacham, Jimmy Kimmel, Pete Davidson and Bruce Springsteen.

The event was filmed and shown on PBS. The broadcast of the ceremony was similar to the previous ceremony, Dave Chappelle: The Kennedy Center Mark Twain Prize for American Humor in 2019, in that it used archival footage of Dave Chappelle performing standup, clips from The Daily Show with Jon Stewart and Stewart's testimony at the congressional hearing for the 9/11 Victim's Compensation Fund.