Winnetou and the Crossbreed (German: Winnetou und das Halbblut Apanatschi) is a 1966 West German Western film directed by Harald Philipp and starring Lex Barker, Pierre Brice, Götz George and Uschi Glas. It is part of the series of Karl May adaptations produced by Rialto Film during the decade. It was co-produced with Italy and Yugoslavia. The budget was an estimated three and a half million Deutschmarks.

This was the first in the series to not be based on a May novel, only on his characters. It was not a box office success, unlike previous releases which had been major hits. However, it did launch the career of Uschi Glas as an important actress.

It was shot at the Spandau Studios in Berlin and on location in Yugoslavia. The film's sets were designed by Vladimir Tadej.