Street of Chance is a 1942 American film noir mystery film directed by Jack Hively and starring Burgess Meredith as a man who finds he has been suffering from amnesia and Claire Trevor as a woman who protects him from the police, who suspect him of murder. He is suspected of the murder of the wealthy Harry Diedrich. The only eyewitness to the murder was Harry's mute grandmother, and she can only communicate with others through sign language.

The story was based on Cornell Woolrich's novel The Black Curtain. It was later dramatized three times on the CBS Radio series Suspense.