Wake Up and Live is a 1937 Fox musical film directed by Sidney Lanfield and produced by Darryl F. Zanuck, starring Jack Haley and Alice Faye plus Walter Winchell and Ben Bernie as themselves.

The film tells the story of a man attempting to overcome his fear of singing into microphones in a manner loosely based upon the principles of the 1936 best-selling self-help book Wake Up and Live! by Dorothea Brande. It also traded on the comedic rivalry Winchell and Bernie had played up throughout the 1930s in newspaper columns and on their radio shows, though they were in fact good friends.

Later in 1937, Wake Up and Live was followed by Love and Hisses - not a direct sequel as such, but another film featuring Winchell and Bernie playing themselves.

In 1944, Wake Up and Live was adapted for radio as an episode of Lux Radio Theatre. The Lux production starred Frank Sinatra, Bob Crosby, Marilyn Maxwell and James Dunn.