Gay Man's Guide to Safer Sex is a safer sex instructional documentary produced by Mike Esser and Tony Carne of Pride Video in association with the Terrence Higgins Trust in 1992. The film was directed by David Lewis and featured a soundtrack by John Balance and Peter Christopherson of Coil. The medical information included in the film is presented by Mike Youle, a British doctor specialising in HIV treatment. In 1997 a sequel was released, directed by Robert Falconer. Gay Man's Guide to Safer Sex '97 featured a radical recut of some of the original scenes asking the British Board of Film Classification to look again at what was permissible and becoming one of the first programmes to discuss the breakthrough of Triple Combination Therapy and the ramifications and personal experiences of living with HIV. The medical information and discussion was again led by Mike Youle. The 1997 film was released on retail video in the UK, Australia and USA and later on DVD. It is still in distribution on DVD.

The film won in the Best Special Interest Category in 1992's British Videogramme Association awards. Gay Man's Guide to Safer Sex '97 premiered to a sellout audience at the BFI National Film Theatre on London's South Bank and was exhibited around the world on the international festival circuit.

In March 2022 the 30th anniversary of the 1992 Gay Man's Guide To Safer Sex was marked at London's Barbican Cinema by a sold-out retrospective screening in Cinema 2. Original Executive Producer Tony Carne and Terrence Higgins Trust Campaigns Director Richard Angell were the guests for a post-show ScreenTalk.

On April 30 2024 Gay Man's Guide To Safer Sex '97 marked 40 years since the discovery that the HIV virus causes AIDS with a sold-out screening in the mainhouse Barbican Cinema 1 of a restored and significantly revised 55-minute 2K Digital Cinema Print of the 2024 Director's Cut. The original star of both films Aiden Brady (as Aiden Shaw in the two Gay Man's Guide films) appeared in the ScreenTalk, along with director and presenter of the 1997 film Rob Falconer, and co-founders of UK HIV awareness and prevention organisation The Love Tank CIC Marc Thompson and Dr. Will Nutland, which was filmed by Barbican Cinema. Original cast members health educator and London Service Director Mark Maguire and Jono Wolf also attended. Prominent London clinics Mortimer Market Centre and 56 Dean Street, and Central North West London NHS Foundation Trust cooperated to launch new PrEP awareness lapel pins and QR code PrEP appointment condom packs at the event.

The return of both films to the cinema screen was spearheaded by Barbican Cinema curator and programmer Alex Davidson who said of the 1997 film and 2024 Director's Cut: "It was like nothing I'd ever seen before – frank and unashamedly sex-positive."