D.O.A. is a 1950 American film noir directed by Rudolph Maté, starring Edmond O'Brien and Pamela Britton. It is considered a classic of the genre. A fatally poisoned man tries to find out who has poisoned him and why. It was the film debuts of Beverly Garland (as Beverly Campbell) and Laurette Luez. In 2004, D.O.A. was selected for preservation in the United States National Film Registry by the Library of Congress as being "culturally, historically, or aesthetically significant."

Leo C. Popkin produced D.O.A. for his short-lived Cardinal Pictures. Due to a filing error, the copyright to the film was not renewed on time, causing it to fall into the public domain: it was subsequently remade as Color Me Dead (1969), D.O.A. (1988), Dead On Arrival (2017), and D.O.A. (2022).