The Search for Signs of Intelligent Life in the Universe (1985) is a one-woman stage show written by Jane Wagner. The original Broadway production starred Lily Tomlin, won the Drama Desk Award for Unique Theatrical Experience, and was turned into a film in 1991.

The show, Tomlin's second Broadway billing as a solo performer, follows Tomlin as she performs various characters or personae, all while wearing simple black pants and a white blouse. The show appears disparate at first, but becomes unified under the sensibility of the opening "bag lady" persona as the performance progresses. The show is often praised or considered controversial for its feminist material, most notably the compressed history of the feminist movement offered in Act 2. For her stage performance, Tomlin won a Tony, Drama Desk, and Outer Critics' Circle awards.

A film version was directed by John Bailey and edited by Sally Menke, and stays true to the original stage performance. The film earned the Golden Space Needle Award at the Seattle International Film Festival. For her efforts on the film, Tomlin received a Funniest Actress in a Motion Picture American Comedy Awards, amongst other notable accolades. A restored version of the film, compiled from different prints, will be shown at the 2024 RescueFest at the Laemmle Monica Film Center in Santa Monica, California in December 2024.