Pratighatana (transl. Resistance) is a 1985 Indian Telugu-language action drama film written and directed by T. Krishna. The film is produced by Ramoji Rao under Ushakiran Movies. The plot follows a woman's fight against corruption and criminalization of politics in India. The film starts Vijayshanti alongside Chandra Mohan, Kota Srinivasa Rao, Sai Kumar, P. L. Narayana, Charan Raj, Suthi Velu, Rajasekhar, Narra Venkateswara Rao, and Y. Vijaya who appear in supporting roles. Music is composed by K. Chakravarthy.

The film is released on 11 October 1985. It was premiered at International Film Festival of India and has garnered the Filmfare Best Film Award (Telugu). The film won six Nandi Awards and two Filmfare Awards South (including Best Film –Telugu). The film was dubbed and released in Tamil as Poo Ondru Puyalanathu. Later it was remade in Malayalam as Pakarathinu Pakaram and in Hindi as Pratighaat while Charan Raj reprise his role in Hindi.