What's Eating Gilbert Grape is a 1993 American coming-of-age drama film directed by Lasse Hallström, and starring Johnny Depp, Juliette Lewis, Mary Steenburgen, Leonardo DiCaprio and John C. Reilly. The film follows the story of Gilbert, a 25-year-old grocery store clerk who is caring for his morbidly obese mother, as well as his mentally disabled younger brother, Arnie. The film takes place in the fictional rural town of Endora, Iowa.

Peter Hedges wrote the screenplay, based on his 1991 novel of the same name. Filming took place from November 1992 to January 1993 in various parts of Texas.

The film was well received, with Depp and DiCaprio's performances garnering critical acclaim. At age 19, DiCaprio received his first nominations for the Academy Award and Golden Globe Award for Best Actor in a Supporting Role, becoming the seventh-youngest Best Supporting Actor nominee for the former.