Affair with a Stranger is a 1953 American comedy-drama directed by Roy Rowland and starring Jean Simmons and Victor Mature. It was originally to be released as Kiss and Run.

The film centres on the rumoured marital troubles of a successful playwright. As various people who came into contact with the couple reminisce about the couple's past, the story of the relationship and the budding affair that is potentially destroying it is told through a series of flashbacks.

Upon release, the film was met with lukewarm reviews, Bosley Crowther of The New York Times calling it "a virtual collection of cliches".