Lonesome Jim is a 2005 American comedy/drama film directed by actor/filmmaker Steve Buscemi. Filmed mostly in the city of Goshen, Indiana, the film stars Casey Affleck as a chronically depressed aspiring writer who moves back into his parents' home after failing to make it in New York City. His older brother (Kevin Corrigan) already lives there with his two daughters. Liv Tyler stars as a good-hearted nurse who begins a sexual relationship with Jim and starts to see him as a potential stepfather for her son.

Lonesome Jim premiered at the 2005 Sundance Film Festival, where it was nominated for the Grand Jury Prize, but it lost to Ira Sachs' Forty Shades of Blue. The screenplay was based on characters and events in author Jim Strouse's life. The entire film was shot on a mini-DV digital video camera instead of actual film.