David and Lisa is a 1962 American drama film directed by Frank Perry. It is based on the second story in the two-in-one novellas Jordi/Lisa and David by Theodore Isaac Rubin; the screenplay, written by Frank Perry's wife Eleanor Perry (née Rosenfeld), tells the story of a bright young man suffering from a mental illness which, among other symptoms, has instilled in him a fear of being touched. This lands him in a residential treatment center, where he meets Lisa, a similarly ill young woman who displays a split personality.

The film earned Frank Perry a nomination for the 1963 Academy Award for Best Director and one for Eleanor Perry for her screenplay.

The film was later adapted into a stage play in 1967 and a made-for-television film in 1998.