Midnight Run is a 1988 American action comedy film directed by Martin Brest and starring Robert De Niro and Charles Grodin. Yaphet Kotto, John Ashton, Dennis Farina, Joe Pantoliano, and Philip Baker Hall play supporting roles.

At the 46th Golden Globe Awards, the film was nominated for Best Motion Picture – Musical or Comedy and Best Actor for De Niro. A critical and commercial success, the film was followed by The Midnight Run Action Pack in 1994, three made for television sequels which did not feature any of the principal actors, although a few characters are carried over from the first film.