Wife vs. Secretary (or Wife Versus Secretary) is a 1936 American romantic comedy drama film starring Clark Gable, Myrna Loy and Jean Harlow. Directed and co-produced by Clarence Brown, it was the fifth of six collaborations between Gable and Harlow and the fourth of seven between Gable and Loy. The screenplay was based on the short story of the same title by Faith Baldwin, published in Cosmopolitan magazine in May 1935. The screenplay was written by Norman Krasna, John Lee Mahin and Alice Duer Miller.

May Robson, George Barbier, Hobart Cavanaugh, and James Stewart appear in support, with Stewart playing the secretary's suitor in one of his first memorable roles.