The Killer Shrews is a 1959 American independent science fiction film directed by Ray Kellogg, and produced by Ken Curtis and Gordon McLendon. The story follows a group of researchers who are trapped in their remote island compound overnight by a hurricane and find themselves under siege by their abnormally large and venomous mutant test subjects. The film stars James Best, Ingrid Goude, Ken Curtis, McLendon, Baruch Lumet and "Judge" Henry Dupree.

Shot outside of Dallas, Texas, it was produced back-to-back with The Giant Gila Monster. Now in the public domain, the film has been issued multiple DVD releases and was lampooned in the fourth season of Mystery Science Theater 3000.