Mr. Show with Bob and David, also known as Mr. Show, is an American sketch comedy series starring and hosted by Bob Odenkirk and David Cross. It aired on HBO from November 3, 1995, to December 28, 1998.

Cross and Odenkirk introduced most episodes as semi-fictionalized versions of themselves, before transitioning to a mixture of on-stage sketches performed in front of a live audience and pre-taped segments. The show featured a number of alternative comedians as both cast members and writers, including Sarah Silverman, Paul F. Tompkins, Jack Black, Karen Kilgariff, Tom Kenny, Mary Lynn Rajskub, Brian Posehn, Jill Talley, Scott Aukerman, and Dino Stamatopoulos.

It was nominated for four Primetime Emmy Awards, as well as a Golden Satellite Award. The show is currently available on Max.