The 2006 Genesis was a professional wrestling pay-per-view (PPV) event produced by Total Nonstop Action Wrestling (TNA), which took place on November 19, 2006 at the TNA Impact! Zone in Orlando, Florida. It was the second event under the Genesis chronology. Eight matches were featured on the event's card. The event was TNA’s highest-selling pay-per-view at the time, domestically selling just over 60,000 buys beating the previously set record of 55,000 at Bound for Glory (2006), and it is still TNA's best-selling pay-per-view outside of their annual pay-per-view events Bound for Glory and Slammiversary.

In October 2017, with the launch of the Global Wrestling Network, the event became available to stream on demand.