Blood-C (stylized as BLOOD-C) is a 2011 Japanese anime television series co-created by studio Production I.G and manga artist group CLAMP. It is the second anime series in the Blood franchise following the 2005–2006 series Blood+. The original 12-episode series aired during 2011, with a sequel film, Blood-C: The Last Dark releasing in Japanese theaters the following year. The anime was subsequently adapted into two manga, a 2011 novelization, a 2015 stage play, and three live-action films.

Blood-C focuses on Saya Kisaragi, an outwardly normal teenage high school girl who serves as a shrine maiden to a country town; in reality, she is a skilled swordswoman charged by her father to defeat Elder Bairns, monsters who feed on human blood. As her battles grow more desperate and more people she cares for fall victim to the Elder Bairns, Saya begins finding faults in her reality, and eventually uncovers a disturbing truth about herself, the town and her surviving friends.

Blood-C was designed to share only thematic similarities with earlier Blood projects. CLAMP was brought on board to both design the characters and help create the scenario. It featured several new elements to the Blood franchise, such as being primarily set within a high school environment. The Elder Bairns were inspired by the Great Old Ones from H. P. Lovecraft's Cthulhu Mythos, and modeled after traditional Japanese monsters. Its bloody violence, a stylistic choice following the series' themes, resulted in censorship in Japan and eventual blacklisting in China. The series has received mixed to positive reviews from journalists.