The 2021 Hell in a Cell was the 13th annual Hell in a Cell professional wrestling pay-per-view (PPV) and livestreaming event produced by WWE. It was held for wrestlers from the promotion's Raw and SmackDown brand divisions. The event took place on June 20, 2021, from the WWE ThunderDome, hosted at the Yuengling Center in Tampa, Florida. It was WWE's final PPV to be broadcast from the ThunderDome, and subsequently the final PPV in WWE's residency at the Yuengling Center, due to the company's resumption of live touring with fans in mid-July. It was the first Hell in a Cell event to be held in June, as the event was generally held in October, and only the second time the event was not held in October, the first of which was the September 2018 edition. It was also the first Hell in a Cell to livestream on Peacock.

Seven matches were contested at the event, including one on the Kickoff pre-show. Two Hell in a Cell matches were contested at the event. In the main event, which was Raw's Hell in a Cell match, Bobby Lashley defeated Drew McIntyre in a Last Chance match to retain the WWE Championship. In the other Hell in a Cell match, which was the opening bout, Bianca Belair defeated Bayley to retain the SmackDown Women's Championship. In other prominent matches, Charlotte Flair defeated Raw Women's Champion Rhea Ripley by disqualification, thus Ripley retained the title, and Seth Rollins defeated Cesaro.