Nero Wolfe is a television series adapted from Rex Stout's series of detective stories that aired for two seasons (2001–2002) on A&E. Set in New York City sometime in the 1940s–1950s, the stylized period drama stars Maury Chaykin as Nero Wolfe and Timothy Hutton as Archie Goodwin. A distinguishing feature of the series is its use of a repertory cast to play non-recurring roles. Nero Wolfe was one of the Top 10 Basic Cable Dramas for 2002.

The series won praise for its high production values and jazzy score by Michael Small, and for preserving the language and spirit of the original stories. Most of the teleplays were written by consulting producer Sharon Elizabeth Doyle and the team of William Rabkin and Lee Goldberg, whose "Prisoner's Base" was nominated for an Edgar Award by the Mystery Writers of America.

A total of 20 episodes were produced over the two-season run. Eight of Stout's novels were adapted into two-hour broadcasts, while 12 of his short stories were filmed as one-hour episodes.

Nero Wolfe was produced for A&E by Jaffe/Braunstein Films, one of the first production companies to use high-definition video for television. Although the second season was shot in HD, none of the several home video releases of the series has been issued in HD, and only one of the 20 episodes ("The Silent Speaker") has been issued in 16:9 widescreen format.