Mother Up! is an adult animated sitcom starring Eva Longoria, that streamed on Hulu in the United States and aired on City in Canada for a single season from 2013 to 2014. The show chronicles the misguided attempts at parenthood of a disgraced music executive who transitions from the big city to suburbia. After she resigns from her job and her husband leaves her, Rudi Wilson becomes a single mother raising her two children, Apple and Dick, and must learn mothering duties. Longoria stars as the main character and serves as executive producer.

Mother Up! premiered on November 6, 2013, with new episodes released on Wednesdays. It made its Canadian television debut on City on January 23, 2014, with new episodes aired on Saturday nights (during its first few weeks it was Thursday nights). The show was developed by Rogers Media and co-produced by Canadian companies Breakthrough Entertainment and Bardel Entertainment, in association with U.S.-based Mass Animation. The show marked Hulu's second foray into animated programming after The Awesomes. It was pitched as "Family Guy for women".The Mother Up! theme song, is written and performed by Lee Anna James in the Hulu release.

The series became available on Breakthrough Entertainment's YouTube channel in mid-2020.