Safe House is a 2012 American action thriller film directed by Daniel Espinosa, written by David Guggenheim, and starring Denzel Washington and Ryan Reynolds. The film follows Matt Weston (Reynolds), a CIA officer on a low-level posting in Cape Town, South Africa, who is in charge of a safe house where the CIA is interrogating Tobin Frost (Washington), a veteran operative accused of betraying the agency. When the safe house is attacked by mercenaries, Weston flees with Frost in his charge. As the team of killers, who seem to be one step ahead of the pair, track them throughout Cape Town, Weston wonders who to trust. Vera Farmiga, Brendan Gleeson, Sam Shepard, Rubén Blades, Nora Arnezeder and Robert Patrick co-star.

Safe House was Espinosa's first English-language film. Filming took place on location in Cape Town. The film premiered in New York City on February 7, 2012, and was released in U.S. theaters on February 10, 2012, by Universal Pictures. The film earned mixed reviews, with praise for Washington and Reynolds' performances, but negative criticisms for the screenplay and the editing of the action scenes. Nevertheless, Safe House was a commercial success, earning $208 million worldwide against an $85 million budget.