UFC Fight Night 100: Bader vs. Nogueira 2 was a mixed martial arts event produced by the Ultimate Fighting Championship held on November 19, 2016, at Ginásio do Ibirapuera in São Paulo, Brazil. The event was initially expected to be headlined by a light heavyweight bout between former two-time UFC Light Heavyweight Championship challenger Alexander Gustafsson and Antônio Rogério Nogueira. Gustafsson pulled out of the bout due to an injury and was replaced by The Ultimate Fighter: Team Nogueira vs. Team Mir light heavyweight winner Ryan Bader.

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