Uncle Tom's Cabin is a 1927 American synchronized sound drama film directed by Harry A. Pollard and released by Universal Pictures. While the film has no audible dialog, it was released with a synchronized musical score with sound effects using the Western Electric sound-on-film process. The film is based on the 1852 novel Uncle Tom's Cabin by Harriet Beecher Stowe and was the last silent version filmed.

In this version of the film, all of the major slave roles, with the exception of Uncle Tom himself, were portrayed by white actors. Actress Mona Ray played the slave Topsy in blackface while the slaves Eliza, George, Cassie, and Harry were all presented as having very light skin coloring because of mixed-race heritage. This film was released on DVD in 1999 by Kino.The title role was originally played by the notable stage actor Charles Gilpin, but he quit amid onset dissatisfaction with the depiction of the role and was replaced by James B. Lowe, reshooting the scenes already filmed with Gilpin.

The film was rereleased in 1958 with sound added and narration by Raymond Massey.