Prometheus is a 2012 science fiction horror film co-produced and directed by Ridley Scott, with the screenplay co-written by Jon Spaihts and Damon Lindelof. It is the fifth installment in the Alien franchise. The film features an ensemble cast including Noomi Rapace, Michael Fassbender, Guy Pearce, Idris Elba, Logan Marshall-Green, and Charlize Theron. Set in the late 21st century, the film centers on the crew of the spaceship Prometheus as it follows a star map discovered among the artifacts of several ancient Earth cultures. Seeking the origins of humanity, the crew arrives on a distant world and discovers a threat that could cause the extinction of the human species.

Scott and director James Cameron developed ideas for a film that would serve as a prequel to Scott's 1979 science-fiction horror film Alien. In 2002, the development of Alien vs. Predator took precedence, and the project remained dormant until 2009 when Scott again showed interest. Spaihts wrote a script for a prequel to the events of the Alien films, but Scott opted for a different direction to avoid repeating cues from those films. In late 2010, Lindelof joined the project to rewrite Spaihts's script, and he and Scott developed a story that precedes the story of Alien but is not directly connected to the original series. According to Scott, although the film shares "strands of Alien's DNA," and takes place in the same universe, Prometheus explores its own mythology and ideas.

Prometheus entered production in April 2010, with extensive design phases during which the technology and creatures that the film required were developed. Principal photography began in March 2011, with an estimated $120–130 million budget. The film was shot using 3D cameras throughout, almost entirely on practical sets, and on location in England, Iceland, Scotland, Jordan and Spain. It was promoted with a marketing campaign that included viral activities on the web. Three videos featuring the film's leading actors in character, which expanded on elements of the fictional universe, were released and met with a generally positive reception and awards.

Prometheus was released on June 1, 2012, in the United Kingdom and on June 8, 2012, in North America. The film earned generally positive reviews, receiving praise for the designs, production values and cast performances, but was criticized for its uneven script and unresolved plot points. The film grossed over $403 million worldwide. A sequel, Alien: Covenant, was released in May 2017, fully tying the film to the Alien franchise.