Y: The Last Man is an American post-apocalyptic drama television series developed by Eliza Clark based on the comic book series of the same name by Brian K. Vaughan and Pia Guerra. In the series, a mysterious cataclysmic event simultaneously kills every mammal with a Y chromosome—except for Yorick Brown and his monkey–and follows him as he traverses the new world.

The series began development at FX in October 2015, with a pilot ordered and filmed in 2018. A first season was greenlit in 2019 with Clark replacing original showrunners Michael Green and Aida Mashaka Croal. Filming began in 2020, with several casting changes, including the lead role of Yorick. It premiered on September 13, 2021, on FX on Hulu, and stars Diane Lane, Ashley Romans, Ben Schnetzer, Olivia Thirlby, and Amber Tamblyn. It received generally positive reviews from critics, but was cancelled in October 2021, after one season. The series was removed from Hulu on May 26, 2023.